So in order to reduce your "risk" of doing a calculation wrong on the exam you may want to do it starting on day 0. However, in "real life" starting on day 1 is more appropriate. The conclusion is that PMI is aware of these varying methods and that you should not see a question on the exam where only the application of any particular method leads to the right answer.Colorectal cancer (CRC) is the fourth most common malignancy and the second leading cause of cancer‐related death in the United States. CRC with locoregional lymph node spread has a 5‐year overall survival (OS) of 70% while spread to distant organs carries a significantly worse prognosis with a 5‐year OS of 12%. 1 Metastasis to the liver is the most frequent site of distant spread 2 while the peritoneal surface is the second most common site of metastasis, involving approximately 10% of patients with CRC at the time of initial presentation and the sole site of recurrence in up to 25% of patients with CRC. 3, 4 Peritoneal metastasis is associated with a poor prognosis with a survival ranging from 5 to 7 months with systemic chemotherapy alone. 5, 6 When compared with other sites of metastasis, PM is associated with a significantly shorter progression‐free survival (PFS) and OS. Molecular profiling has been used to identify predictive and prognostic biomarkers and identify novel therapeutic targets for patients with metastatic CRC. 8 Approximately, 40% of CRC are characterized by mutations in the KRAS gene.
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